Keanu Reeves

Character: Bob Arctor

Robert Downey Jr.

Character: James Barris

Woody Harrelson

Character: Ernie Luckman

Winona Ryder

Character: Donna Hawthorne

Rory Cochrane

Character: Charles Freck

Mitch Baker

Character: Brown Bear Lodge Host

Sean Allen

Character: Additional Fred Scramble Suit Voice (voice)

Cliff Haby

Character: Voice from Headquarters (voice)

Steven Chester Prince

Character: Cop

Natasha Valdez

Character: Waitress

Mark Turner

Character: Additional Hank Scramble Suit Voice (voice)

Chamblee Ferguson

Character: Medical Deputy #2

Angela Rawna

Character: Medical Deputy #1

Eliza Stevens

Character: Arctor's Daughter #1

Sarah Menchaca

Character: Arctor's Daughter #2

Melody Chase

Character: Arctor's Wife

Leif Anders

Character: Freck Suicide Narrator (voice)

Turk Pipkin

Character: Creature

Alex E. Jones

Character: Street Prophet

Lisa Marie Newmyer

Character: Connie

Wilbur Penn

Character: Medical Officer #1

Ken Webster

Character: Medical Officer #2

Hugo Perez

Character: New Path Staff Member #1

Rommel Sulit

Character: New Path Staff Member #2

Dameon Clarke

Character: Mike

Ryan Melton

Character: New Path Resident #1

Leila Plummer

Character: New Path Resident #2

Jason Douglas

Character: New Path Farm Manager

Marco Perella

Character: Donald

Gary Teague

Character: Brown Bear Lodge Member (uncredited)