Joel McCrea

Character: William Thomas Green Morton

Betty Field

Character: Elizabeth Morton

Harry Carey

Character: Professor John C. Warren

William Demarest

Character: Eben Frost

Louis Jean Heydt

Character: Dr. Horace Wells

Julius Tannen

Character: Dr. Charles T. Jackson

Edwin Maxwell

Character: Vice-President of Medical Society

Porter Hall

Character: President Franklin Pierce

Franklin Pangborn

Character: Dr. Heywood

Grady Sutton

Character: Homer Quimby

Donivee Lee

Character: Betty Morton

Harry Hayden

Character: Judge Shipman

Torben Meyer

Character: Dr. Dahlmeyer

Victor Potel

Character: First Dental Patient

Thurston Hall

Character: Senator Borland

J. Farrell MacDonald

Character: The Priest

Roscoe Ates

Character: Morton's Sign Painter - replaced by Hank Worden (uncredited)

Hank Bell

Character: Onlooker (uncredited)

Franklyn Farnum

Character: Massachusetts Medical Society Man (uncredited)

Byron Foulger

Character: Morton's Clinic Manager (uncredited)

Hank Worden

Character: Morton's Sign Painter - replaced Roscoe Ates (uncredited)

Arthur Hoyt

Character: Presidential Secretary (uncredited)