Ryan Reynolds

Character: Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Character: Cable

Morena Baccarin

Character: Vanessa

Julian Dennison

Character: Firefist

Zazie Beetz

Character: Domino

T.J. Miller

Character: Weasel

Leslie Uggams

Character: Blind Al

Karan Soni

Character: Dopinder

Brianna Hildebrand

Character: Negasonic Teenage Warhead

Jack Kesy

Character: Black Tom

Eddie Marsan

Character: Headmaster

Shioli Kutsuna

Character: Yukio

Stefan Kapičić

Character: Colossus (voice)

Randal Reeder

Character: Buck

Nikolai Witschl

Character: Head Orderly Frye

Thayr Harris

Character: Sergei Valishnikov

Rob Delaney

Character: Peter

Lewis Tan

Character: Shatterstar

Bill Skarsgård

Character: Zeitgeist

Terry Crews

Character: Bedlam

Brad Pitt

Character: Vanisher

Paul Wu

Character: Hong Kong Boss

Robert Maillet

Character: Sluggo

Alan Tudyk

Character: Luke - Redneck #1

Matt Damon

Character: Redneck #2

Michasha Armstrong

Character: Swat Captain (School)

Joe Doserro

Character: Bus Driver

Hayley Sales

Character: Cable's Wife

Islie Hirvonen

Character: Cable's Daughter

Jagua Arneja

Character: Tree Trimmer #1

Gerry South

Character: Tree Trimmer #2

Mike Dopud

Character: Prison Guard

Luke Roessler

Character: Cereal Kid

Andy Canete

Character: Neighbor #1

Tanis Dolman

Character: Neighbor #2

Eleanor Walker

Character: Neighbor #3

Hunter Dillon

Character: Branding Boy

Sala Baker

Character: Older Firefist

Sonia Sunger

Character: News Reporter (Irene)

Paul Wernick

Character: News Cameraman

Rhett Reese

Character: News Helicopter Pilot

Abiola Uthman

Character: Chinook Pilot

Tony Bailey

Character: Black Tom Gang Member

David Cook

Character: Priest

Alex Kliner

Character: Park Bench Couple

Elaine Kliner

Character: Park Bench Couple

David Leitch

Character: Ground Chuck Mutant

Valencia Budijanto

Character: Zoo Kid

Stefania Indelicato

Character: Bystander

Myfanwy Williams

Character: Strip Club Dancer

Sam Armstrong

Character: Strip Club Dancer

Alison Pickford

Character: Strip Club Dancer

Danny Ocean

Character: Strip Club Baddie

Paul Lazenby

Character: Strip Club Baddie

Noah Beggs

Character: Strip Club Baddie

Andrei Kovski

Character: Strip Club Baddie

Alicia Morton

Character: Vocalist on 'Tomorrow' (voice)

Andre Tricoteux

Character: On-Set Colossus (uncredited)

Lisa Bunting

Character: Child Protection Worker (uncredited)

Miles Ellis

Character: Waving Prisoner (uncredited)

Lars Grant

Character: Prison Guard 96S (uncredited)

Sam Hargrave

Character: DMC Guard (uncredited)

Nicholas Hoult

Character: Beast (uncredited)

Simon MacIntyre

Character: Business Passerby (uncredited)

James McAvoy

Character: Charles Xavier (uncredited)

Evan Peters

Character: Quicksilver (uncredited)

Tye Sheridan

Character: Cyclops (uncredited)

Alexandra Shipp

Character: Storm (uncredited)

Kodi Smit-McPhee

Character: Nightcrawler (uncredited)

Scott Vickaryous

Character: Thug (uncredited)

Dan Zachary

Character: Mutant Prisoner (uncredited)