Owen Wilson

Character: Marmaduke (voice)

Emma Stone

Character: Mazie (voice)

George López

Character: Carlos (voice)

Caroline Sunshine

Character: Barbara Winslow

Finley Jacobsen

Character: Brian Winslow

Steve Coogan

Character: Raisin (voice)

Christopher Mintz-Plasse

Character: Giuseppe (voice)

Fergie

Character: Jezebel (voice)

Kiefer Sutherland

Character: Bosco (voice)

Lee Pace

Character: Phil Winslow

Judy Greer

Character: Debbie Winslow

Damon Wayans Jr.

Character: Thunder (voice)

Marlon Wayans

Character: Lightning (voice)

Sam Elliott

Character: Chupadogra (voice)

William H. Macy

Character: Don Twombly

David Walliams

Character: Anton Harrison

Glenn McCuen

Character: Bodie

Raugi Yu

Character: Drama Trainer

Chris Colfer

Character: Drama Dog #2 (voice)

Josh Gad

Character: Bandana Dog (voice)

Ash Lee

Character: Male Executive

Heather Doerksen

Character: Female Executive

Madison Desjarlais

Character: Brunette Girl

Nicole Muñoz

Character: 3rd OC Girl

Christopher Attadia

Character: Jock

Jason Bryden

Character: Man on Bench

Frank Topol

Character: Buff Owner

Izaak Smith

Character: Basketball Captain

Keith Dallas

Character: Emergency Road Worker

P.J. Prinsloo

Character: Lead Fireman

Colin Decker

Character: Fireman

Charles Jarman

Character: Fireman

Garvin Cross

Character: Fireman

Chris Bradford

Character: Fireman

Hope Levy

Character: Afghan #1 (voice)

Randall Montgomery

Character: Sweater Dog (voice)

Anjelah Johnson-Reyes

Character: Afghan #2 (voice)

Devon Werkheiser

Character: Drama Dog #1 / Shroom Dog #2 / Golden Dog / Cocker Spaniel (voice)

Hudson Thames

Character: Delinquent Dog (voice)

Francisco Ramos

Character: Purse Dog #1 (voice)

Bernardo de Paula

Character: Purse Dog #2 (voice)

Eddie 'Piolin' Sotelo

Character: Purse Dog #3 (voice)

Jack McGee

Character: Dalmatian (voice)

Liza Lapira

Character: Party Dog #1 (voice)

King Kedar

Character: Surfing Award Dog / Beach Dog #4 (voice)

Todd Glass

Character: Doberman / Shasta (voice)

Ryan Devlin

Character: Beach Dog #2 (voice)

Jeffrey Garcia

Character: Beach Dog #3 (voice)