John Wayne

Character: John Chisum

Forrest Tucker

Character: Lawrence Murphy

Christopher George

Character: Dan Nodeen

Ben Johnson

Character: James Pepper

Glenn Corbett

Character: Pat Garrett

Andrew Prine

Character: Alex McSween

Bruce Cabot

Character: Sheriff Brady

Patric Knowles

Character: Henry Tunstall

Richard Jaeckel

Character: Jess Evans

Lynda Day George

Character: Sue McSween

Geoffrey Deuel

Character: Billy 'The Kid' Bonney

Pamela McMyler

Character: Sallie Chisum

John Agar

Character: Amos Patton

Lloyd Battista

Character: Neemo

Robert Donner

Character: Bradley Morton

Christopher Mitchum

Character: Tom O'Folliard

Edward Faulkner

Character: James J. Dolan

Ray Teal

Character: Justice J.B. Wilson

Ron Soble

Character: Charley Bowdre

John Mitchum

Character: Baker

Glenn Langan

Character: Colonel Nathan Dudley

Alan Baxter

Character: Gov. Sam Axtell

Alberto Morin

Character: Juan Delgado

William Bryant

Character: Jeff - Head Wrangler

Pedro Armendáriz Jr.

Character: Ben

John Pickard

Character: Sgt. Braddock

Abraham Sofaer

Character: Chief White Buffalo

Gregg Palmer

Character: Karl Riker

Hank Worden

Character: Stationmaster Elwood

Pedro Gonzalez Gonzalez

Character: Mexican Rancher

Jim Burk

Character: Trace - Wrangler

Eddy Donno

Character: Cass

Bob Morgan

Character: Pegleg on Street

William Conrad

Character: Narrator - Opening Credits (voice) (uncredited)

José Ángel Espinosa 'Ferrusquilla'

Character: Governor's Aide (uncredited)

Ron Fletcher

Character: Doctor (uncredited)

'Chico' Hernandez

Character: Boy on Town (uncredited)

John Kelly

Character: Minister (uncredited)

Cliff Lyons

Character: Wrangler (uncredited)

Josh McLaglen

Character: Young Boy Loading Wagon (uncredited)

Mary McLaglen

Character: Young Girl (uncredited)

Lee Meriwether

Character: Sallie's Mother (picture in Chisum's Pocketwatch) (uncredited)

Chuck Roberson

Character: Trail Herder (uncredited)

José Torvay

Character: Mexican Blacksmith (uncredited)

José Trinidad Villa

Character: Blacksmith (uncredited)

Ralph Volkie

Character: Blacksmith (uncredited)

Henry Wills

Character: Extra (uncredited)