Storm Reid

Character: Meg Murry

Oprah Winfrey

Character: Mrs. Which

Reese Witherspoon

Character: Mrs. Whatsit

Mindy Kaling

Character: Mrs. Who

Levi Miller

Character: Calvin O'Keefe

Deric McCabe

Character: Charles Wallace Murry

Chris Pine

Character: Dr. Alex Murry

Gugu Mbatha-Raw

Character: Dr. Kate Murry

Zach Galifianakis

Character: The Happy Medium

Rowan Blanchard

Character: Veronica Kiley

Michael Peña

Character: Red

André Holland

Character: Principal Jenkins

Bellamy Young

Character: Camazotz Woman

David Oyelowo

Character: The It (voice)

Conrad Roberts

Character: Elegant Man

Lyric Wilson

Character: Young Meg

Yvette Cason

Character: Mrs. Teacher

Will McCormack

Character: Mr. Teacher

Daniel MacPherson

Character: Calvin's Father

Akemi Look

Character: Air Force Officer

Tim Kang

Character: School Superintendent

Michele Norris

Character: Radio News Broadcaster (voice)

Claire Montwill

Character: Student

Catelynn Brown

Character: Meg Double

Ariyah Brown

Character: Meg Double

Losa Fifita

Character: Meg Double

Joyce Larkin

Character: Mrs. Who Double

Teonee Motley

Character: Mrs. Which Double

Jessica Rockwell

Character: Mrs. Whatsit Double

Oz Kalvan

Character: Charles Wallace Double

Isaac Ordonez

Character: Charles Wallace Double

Kai Miller

Character: Charles Wallace Double

Leighton Leevard

Character: Charles Wallace Double

Guillaume Seeleuthner

Character: Charles Wallace Double

Jacob Eddington

Character: Charles Wallace Double

Easton Tath

Character: Baby Charles Wallace

Giselle Paredes

Character: Baby Charles Wallace

Punnavith Koy

Character: