Hank Azaria

Character: Gargamel

Neil Patrick Harris

Character: Patrick Winslow

Jayma Mays

Character: Grace Winslow

Jonathan Winters

Character: Papa Smurf (voice)

Katy Perry

Character: Smurfette (voice)

Anton Yelchin

Character: Clumsy Smurf (voice)

Sofía Vergara

Character: Odile Anjelou

Tim Gunn

Character: Henri

Frank Welker

Character: Azrael (voice)

Madison McKinley

Character: Model

Meg Phillips

Character: Model

Mahadeo Shivraj

Character: Cabbie

Julie Chang

Character: Newscaster

Mark Doherty

Character: Bluetooth Businessman

Minglie Chen

Character: Young Woman

Sean Kenin

Character: Guy in Plaid Shirt

Victor Pagan

Character: Bum

Adria Baratta

Character: Anjelou Employee

Paula Pizzi

Character: Odile's Mother

Andrew Sellon

Character: Waiter

Julianna Rigoglioso

Character: Little Sister

Daria Rae Figlo

Character: Blonde Sister

Bradley Gosnell

Character: Toy Salesperson

Heidi Armbruster

Character: Toy Store Parent

Finnerty Steeves

Character: Toy Store Parent

John Speredakos

Character: Parent with Girls

Skai Jackson

Character: Kicking Girl

Alex Hall

Character: Skateboard Kid

Eric Redgate

Character: Skateboard Kid

Jojo Gonzalez

Character: FAO Custodian

Scott Dillin

Character: Cop

Tyree Michael Simpson

Character: Cop

Sean Ringgold

Character: Inmate Bubba

Mario D'Leon

Character: Bubba's Inmate Friend

Liz Smith

Character: Party Guest

Tom Colicchio

Character: Party Guest

Michael Musto

Character: Party Guest

Joan Rivers

Character: Party Guest

Olivia Palermo

Character: Party Guest

Julia Enescu

Character: Party Guest

Lauren Waggoner

Character: Party Guest

Mr. Krinkle

Character: Azrael

Hank

Character: Elway

Alan Cumming

Character: Gutsy Smurf (voice)

Fred Armisen

Character: Brainy Smurf (voice)

George López

Character: Grouchy Smurf (voice)

Kenan Thompson

Character: Greedy Smurf (voice)

Jeff Foxworthy

Character: Handy Smurf (voice)

John Oliver

Character: Vanity Smurf (voice)

Wolfgang Puck

Character: Chef Smurf (voice)

Gary Basaraba

Character: Hefty Smurf (voice)

Paul Reubens

Character: Jokey Smurf (voice)

B. J. Novak

Character: Baker Smurf (voice)

Tom Kane

Character: Narrator Smurf (voice)

John Kassir

Character: Crazy Smurf (Voice)

Joel McCrary

Character: Farmer Smurf (voice)

Mary McGloin

Character: Mother of Girl in Store (uncredited)