Robert Downey Jr.

Character: Peter Highman

Zach Galifianakis

Character: Ethan Tremblay

Michelle Monaghan

Character: Sarah Highman

Jamie Foxx

Character: Darryl

Juliette Lewis

Character: Heidi

Danny McBride

Character: Lonnie

RZA

Character: Airport Screener

Matt Walsh

Character: TSA Agent

Brody Stevens

Character: Limo Driver

Jakob Ulrich

Character: Patrick

Naiia Ulrich

Character: Alex

Todd Phillips

Character: Barry

Bobby Tisdale

Character: Carl

Sharon Conley

Character: Airport X-Ray

Nathalie Fay

Character: Flight Attendant

Emily Wagner

Character: Flight Attendant

Steven M. Gagnon

Character: Air Marshall

Paul Renteria

Character: Border Guard

Marco Rodríguez

Character: Federali Agent

Mimi Kennedy

Character: Sarah's Mom

Tymberlee Hill

Character: New Mother

Keegan-Michael Key

Character: New Father

Aaron Lustig

Character: Dr. Greene

Charlie Sheen

Character: Charlie Harper

Jon Cryer

Character: Alan Harper

Haji Abdullah

Character: Airport Passenger (uncredited)

Jeremy Ambler

Character: TSA Agent (uncredited)

Madeline Brumby

Character: Airport Pedestrian (uncredited)

Joseph Harold

Character: Private Johnson (uncredited)

Sarah Reagin Clemmensen

Character: Airport Security Agent (uncredited)

Connie Sawyer

Character: Elderly Airport Passenger (uncredited)