Anna Faris

Character: Cindy Campbell

Simon Rex

Character: George

Anthony Anderson

Character: Mahalik

Charlie Sheen

Character: Tom

Regina Hall

Character: Brenda Meeks

Leslie Nielsen

Character: President Baxter Harris

Kevin Hart

Character: CJ

Jeremy Piven

Character: Ross Giggins

Pamela Anderson

Character: Becca

Jenny McCarthy

Character: Kate

Denise Richards

Character: Annie

Elaine Klimaszewski

Character: Elaine

Diane Klimaszewski

Character: Diane

Drew Mikuska

Character: Cody

Jianna Ballard

Character: Sue

George Carlin

Character: Architect

Queen Latifah

Character: Aunt Shaneequa / The Oracle

Eddie Griffin

Character: Orpheus

Camryn Manheim

Character: Trooper Champlin

Marny Eng

Character: Tabitha

Timothy Stack

Character: Carson Ward

Darrell Hammond

Character: Father Muldoon

Dexter Bell

Character: Toilet Guy

Dame Lee

Character: Rapper #1

Doron Bell

Character: Rapper #2

Simon Cowell

Character: Simon Cowell

Fat Joe

Character: Fat Joe

Ajay Naidu

Character: Sayaman

William S. Taylor

Character: Mr. Meeks

Patricia Idlette

Character: Mrs. Meeks

David Edwards

Character: Ralph

Frank C. Turner

Character: Mr. Meek's Brother

Monica Dillon

Character: Brenda's Grandmother

Lori Stewart

Character: Tabitha's Mother

Jim Bremner

Character: Guy in Chair

Phil Dornfeld

Character: Tabitha's Voice (voice)

Edward Moss

Character: MJ

Dee Jay Jackson

Character: Zubie

D.L. Hughley

Character: John Wilson

Ja Rule

Character: Agent Thompson

Macy Gray

Character: Macy Gray

Redman

Character: Redman

Method Man

Character: Method Man

Raekwon

Character: Raekwon

RZA

Character: RZA

U-God

Character: U-God

Troy Yorke

Character: Alien #1

Marco Soriano

Character: Alien #2

Cliff Solomon

Character: Native American #1

Byron Chief-Moon

Character: Native American #2

Dolly Madsen

Character: Native American #3

John Hainsworth

Character: Tracheotomy Man

Beverley Breuer

Character: Tracheotomy Wife

Jessie Young

Character: Girl Scout

Deanne Henry

Character: Tammy Fae Baker

Eric Breker

Character: Secret Serviceman Jones

Naomi Lawson-Baird

Character: Sweet Tabitha

Abigail Adams

Character: Wedding Guest

Master P

Character: P Masters

Debbie Lee Carrington

Character: Mini Tabitha (uncredited)

Frank Meschkuleit

Character: Additional Performances (puppeteer)