William Bendix

Character: George Herman 'Babe' Ruth

Claire Trevor

Character: Claire Hodgson Ruth

Charles Bickford

Character: Brother Matthias

Sam Levene

Character: Phil Conrad

William Frawley

Character: Jack Dunn

Gertrude Niesen

Character: Nightclub Singer

Fred Lightner

Character: Miller Huggins

Stanley Clements

Character: Western Union Boy

Robert Ellis

Character: Babe Ruth as a Boy (as Bobby Ellis)

Lloyd Gough

Character: Gambler Dalton

Matt Briggs

Character: Colonel Jacob Ruppert

Paul Cavanagh

Character: Dr. Menzies

Warren Douglas

Character: Boston Braves' Rookie

Pat Flaherty

Character: Bill Carrigan, Red Sox Manager

Mark Koenig

Character: Mark Koenig

Richard Lane

Character: Boston Braves' coach

Ziggy Sears

Character: Umpire Ziggy Sears

Bucky Harris

Character: Bucky Harris - Baseball Player

Harry Wismer

Character: Harry Wismer - Sports Announcer

Mel Allen

Character: Mel Allen - New York Yankees Radio Announcer

H.V. Kaltenborn

Character: H. V. Kaltenborn - Radio News Commentator

Knox Manning

Character: Narrator

Al Bain

Character: Barfly (uncredited)

Oliver Crawford

Character: Reporter (uncredited)