Robin Wright

Character: Pippa Lee

Alan Arkin

Character: Herb Lee

Keanu Reeves

Character: Chris Nadeau

Julianne Moore

Character: Kat

Winona Ryder

Character: Sandra Dulles

Mike Binder

Character: Sam Shapiro

Cornel West

Character: Don Sexton

Zoe Kazan

Character: Grace Lee

Maria Bello

Character: Suky Sarkissian

Shirley Knight

Character: Dot Nadeau

Blake Lively

Character: Young Pippa Lee

Monica Bellucci

Character: Gigi Lee

Madeline McNulty

Character: Young Pippa, 7

Adam Shonkwiler

Character: Chester Sarkissian - Age 22

Myra Lucretia Taylor

Character: Night Nurse

Robin Weigert

Character: Aunt Trish

Ryan McDonald

Character: Ben Lee

Tim Guinee

Character: Des Sarkissian

Christin Sawyer Davis

Character: Shelly

Joan Copeland

Character: Piano Player

Arnie Burton

Character: Doctor

Billy Wheelan

Character: Waiter

Drew Beasley

Character: Chester Sarkissian, 6

J.R. Horne

Character: Johnnie Nadeau

Richard DeDomenico

Character: Elderly Man

Dan De Luca

Character: Craig Simms (as Zero)

Adam Grupper

Character: Max Kessler

Sean-Michael Bowles

Character: Jed

Audrey Lynn Weston

Character: Terry

Angela Trento

Character: Woman

Annie Purcell

Character: Nurse

Teresa Yenque

Character: Alphonsa

Lola Pashalinski

Character: Mrs. Mankievitz