Paul Giamatti

Character: Richard Grimes

Kathryn Hahn

Character: Rachel Biegler

Kayli Carter

Character: Sadie Barrett

Molly Shannon

Character: Cynthia Grimes

John Carroll Lynch

Character: Charlie Grimes

Desmin Borges

Character: Sam

Denis O'Hare

Character: Dr. Dordick

Siobhan Fallon Hogan

Character: Beth

Emily Robinson

Character: Charlotte Grimes

Tracee Chimo

Character: Caroline

Amaya Press

Character: Trick or Treat Girl

Francesca Root-Dodson

Character: Fiona

Samantha Buck

Character: Psychologist

Kerry Flanagan

Character: Receptionist

Danny Deferrari

Character: Jonathan

Alyssa Cheatham

Character: Caroline's Daughter

Kelly Miller

Character: Dr. Russell

Fenton Lawless

Character: Uncle Bob

Gabrielle Reidy

Character: Clinic Nurse #3

Caroline Martin

Character: Clinic Nurse

Hettienne Park

Character: Female Doctor

Maddie Corman

Character: Liz

Katrine Hoyt

Character: Nurse with Devil Horns (uncredited)