Lupita Nyong'o

Character: Adelaide Wilson / Red

Winston Duke

Character: Gabe Wilson / Abraham

Elisabeth Moss

Character: Kitty Tyler / Dahlia

Tim Heidecker

Character: Josh Tyler / Tex

Shahadi Wright Joseph

Character: Zora Wilson / Umbrae

Evan Alex

Character: Jason Wilson / Pluto

Yahya Abdul-Mateen II

Character: Russell Thomas / Weyland

Anna Diop

Character: Rayne Thomas / Eartha

Cali Sheldon

Character: Becca Tyler / Io

Noelle Sheldon

Character: Lindsey Tyler / Nix

Madison Curry

Character: Young Adelaide Wilson / Young Red

Ashley McKoy

Character: Teenage Adelaide Wilson / Teenage Red

Napiera Groves

Character: Dr. Foster

Lon Gowan

Character: Don

Alan Frazier

Character: Ferdie / Jeremiah

Duke Nicholson

Character: Danny / Tony

Dustin Ybarra

Character: Troy / Brand

Nathan Harrington

Character: Glen / Jack

Kara Hayward

Character: Nancy / Syd

Jordan Peele

Character: Dying Rabbit / Fun House Narrator (voice) (uncredited)

Darrel Cherney

Character: News Anchor (uncredited)

James Cobb

Character: Don (uncredited)

Alessandro Garcia

Character: EMT (uncredited)

David M Sandoval Jr.

Character: Father of Family on Beach (uncredited)