Sean Penn

Character: Paul Rivers

Naomi Watts

Character: Cristina Peck

Benicio del Toro

Character: Jack Jordan

Charlotte Gainsbourg

Character: Mary Rivers

Danny Huston

Character: Michael Peck

Melissa Leo

Character: Marianne Jordan

Clea DuVall

Character: Claudia

Carly Nahon

Character: Cathy

Claire Pakis

Character: Laura

Nick Nichols

Character: Boy

John Rubinstein

Character: Gynecologist

Eddie Marsan

Character: Reverend John

Loyd Keith Salter

Character: Fat Man

Antef A. Harris

Character: Basketball Guy

Marc Musso

Character: Freddy

Teresa Delgado

Character: Gina

Trent Dee

Character: Guard

Tony Guyton

Character: Guard #2

Wayne E. Beech, Jr.

Character: Inmate #1

Keith Lamont Johnson

Character: Inmate #2

David Chattam

Character: Caddie #1

John Boyd West

Character: Caddie #2

Jeff Schmidt

Character: Caddie #3

Tony Vaughn

Character: Al

Paul Calderon

Character: Brown

Denis O'Hare

Character: Dr. Rothberg

Anastasia Herin

Character: Dolores

Carlo Alban

Character: Lucio

Hai Quang Tran

Character: Cashier

Annie Corley

Character: Trish

Sharon Bishop

Character: Receptionist

Jerry Chipman

Character: Cristina's Father

Tom Irwin

Character: Dr. Jones

Roberto Medina

Character: Dr. Molina

Arita Trahan

Character: Dr. Badnews

Rodney Ingle

Character: Barman

Catherine Dent

Character: Ana

Kevin Chapman

Character: Alan

Randall Hartzog

Character: Friend #1

Verda Davenport

Character: Friend #2

Dorothy Armstrong-Miles

Character: Female Friend #1

Barclay Roberts

Character: Male Friend #1

Lisa Sanchez

Character: Wife

Stephen Bridgewater

Character: P.I.

Michael Finnell

Character: Fat Prisoner

Juan Corrigan

Character: Valet

Charlie B. Brown

Character: Night Guard

Arron Shiver

Character: Young Doctor

Pamela Blair

Character: Doctor

Jennifer Pfalzgraff

Character: Nurse

Lew Temple

Character: County Sheriff

Tricia Branch

Character: Skinny Woman

Jessica Scott

Character: Cocktail Waitress (uncredited)