Peter Weller

Character: Bruce Wayne / Batman (voice)

Ariel Winter

Character: Carrie Kelley / Robin (voice)

David Selby

Character: Commissioner James Gordon (voice)

Wade Williams

Character: Harvey Dent / Two-Face (voice)

Michael Emerson

Character: Joker (voice)

Dee Bradley Baker

Character: Don / Fat Mutant / Additional Voices (voice)

María Canals-Barrera

Character: Commissioner Ellen Yindel (voice)

Paget Brewster

Character: Lana Lang (voice)

Richard Doyle

Character: The Mayor (voice)

Michael Jackson

Character: Alfred Pennyworth (voice)

Yuri Lowenthal

Character: The Son of Batman / Rookie Police Officer (voice)

Michael McKean

Character: Dr. Bartholomew Wolper (voice)

James Patrick Stuart

Character: Murray / Radio Voice (voice)

James Arnold Taylor

Character: Mr. Hudson / Spud (voice)

Bruce Timm

Character: Thomas Wayne / Hydrant Fireman (voice)

Frank Welker

Character: Mayor Stevenson / Weather Man (voice)

Gary Anthony Williams

Character: Mutant Leader / Anchor Bill (voice)

Rob Paulsen

Character: Jeff Adams (voice)

Mark Valley

Character: Clark Kent / Superman (voice)

Robin Atkin Downes

Character: Oliver Queen (voice)

Tress MacNeille

Character: Selina Kyle / Bruno / Old Woman(voice)

Jim Meskimen

Character: President Ronald Reagan (voice)

Conan O'Brien

Character: David Endochrine (voice)

Andy Richter

Character: Frank (voice, uncredited)

Grey DeLisle

Character: Anchor Carla / Female Mutant (voice)

Gary Anthony Sturgis

Character: Silk / Other Spike / Young Mutant (voice)

Carlos Alazraqui

Character: Hernando / TV Host (voice)

Cathy Cavadini

Character: Joanie / Woman with Hot Dog (voice)

Greg Eagles

Character: Mackie / Ben Derrick (voice)

Townsend Coleman

Character: Morrie / Civilian (voice)

Maurice LaMarche

Character: Dr. Willing / News Anchor (voice)

Sam McMurray

Character: Anchor Ted (voice)

Tara Strong

Character: Young Bruce Wayne / Additional Voices (voice)

Andrea Romano

Character: Woman / Police Dispatch / Woman #2 (voice)

Gwendoline Yeo

Character: Lola Chong (voice)

Manny Jacobs

Character: Merkel (voice)

Jim Wise

Character: Femur (voice)

Lex Lang

Character: Rescued Man (voice)

Jason Charles Miller

Character: Axe Fireman (voice)