Keanu Reeves

Character: Ted

Alex Winter

Character: Bill

Kristen Schaal

Character: Kelly

Samara Weaving

Character: Thea

Jack Haven

Character: Billie

William Sadler

Character: Death

Anthony Carrigan

Character: Dennis Caleb McCoy

Erinn Hayes

Character: Elizabeth

Jayma Mays

Character: Joanna

Hal Landon Jr.

Character: Chief Logan

Beck Bennett

Character: Deacon

Kid Cudi

Character: Kid Cudi

Amy Stoch

Character: Missy

Holland Taylor

Character: The Great Leader

Jillian Bell

Character: Dr. Taylor Wood

Dave Grohl

Character: Dave Grohl

DazMann Still

Character: Jimi Hendrix

Jeremiah Craft

Character: Louis Armstrong

Sharon Gee

Character: Ling Lun

Patty Anne Miller

Character: Grom

George Carlin

Character: Rufus Hologram (archive footage)

Piotr Michael

Character: Rufus (voice)

Shoshana Bean

Character: First Noble

Sharon K. London

Character: Second Noble

Al Vicente

Character: Lead Scientist

Jared Bankens

Character: Jesus / Young Ted

Ed Solomon

Character: Stupid Demon

Chris Matheson

Character: Ugly Demon

Kelly Carlin-McCall

Character: Head Technician

Mickey Gooch Jr.

Character: Clete

Billy Slaughter

Character: Young Bill

Reece Loustalot

Character: Babe Ruth

William E. Harris

Character: George Washington

Kimberly Stockton

Character: Queen Elizabeth

Chief Xian aTunde Adjuah

Character: Noble

Bridget Andrews

Character: Cleopatra

Artis Burney

Character: Buddha

Gretchen Byers

Character: Renaissance Lady

Georgia Cohran

Character: Harriet Tubman

David Calloway

Character: Roman Soldier

John Devilman

Character: Roman Soldier

Bailie Duzaut

Character: Female Celt

Andrea Garcia

Character: Gypsy

Gabriel Derrick

Character: Gypsy

Maddison Nicolosi

Character: Gypsy

Kallie Glidewell

Character: Flapper

Xavier Leblanc

Character: Pharaoh

Joseph Martin

Character: Elizabethan Nobleman

Kharismisa Morris

Character: Josephine Baker

Ned Yousef

Character: Gandhi

Eliana Ruiz

Character: Indira Gandhi

Tommie Wong

Character: Kubla Khan

Lindy Ariff

Character: Amelia Earhart

Diana Barnes

Character: Frida

Alberto Corrales

Character: Spanish Count

Scott Gelpi

Character: Native Chief

Andrian Harabaru

Character: Cellist

Dylan Langlois

Character: Rifleman

Nick Garrison

Character: Hendrix Band Member

Jeff Pagano

Character: Noelle Redding

Dijon Lodree

Character: Caveman

Jeremy Thomas

Character: Caveman

Alexis Long

Character: Cavewoman

Suzy Cole

Character: Scientist

Alex Halpern

Character: Scientist

Kierra Luv

Character: Scientist

Bill Prady

Character: Scientist

Nicolas Bosc

Character: Caveman (uncredited)

Daniel Dorr

Character: Mozart (uncredited)

Gregory Hobson

Character: Tough Prisoner (uncredited)

'Weird Al' Yankovic

Character: Guy Playing Accordion (uncredited)

William Buster Benefield

Character: Wedding Guest (uncredited)

Michael Biss

Character: Umpire (uncredited)

Maydelle Clarice

Character: Renaissance Dancer (uncredited)

Guillermo Rodriguez

Character: Guy in Shower (uncredited)

Matt Gorman

Character: Fan Playing Air Guitar (uncredited)

John Morzen

Character: Man in Lounge (uncredited)

Julia Holt

Character: Tambourine Player (uncredited)