Russell Brand

Character: E.B (voice)

James Marsden

Character: Fred

Kaley Cuoco

Character: Samantha O'Hare

Hank Azaria

Character: Carlos / Phil (voice)

Elizabeth Perkins

Character: Bonnie O'Hare

Gary Cole

Character: Henry O'Hare

Hugh Laurie

Character: E.B.'s Dad (voice)

David Hasselhoff

Character: David Hasselhoff

Chelsea Handler

Character: Mrs. Beck

Dustin Ybarra

Character: Cody

Tiffany Espensen

Character: Alex O'Hare

Jimmy Carter

Character: Blind Boys of Alabama

Veronica Alicino

Character: Waitress

Coleton Ray

Character: Young Fred

Mark Riccardi

Character: Security Guard

Greg Lewis

Character: Performer

Hugh Hefner

Character: Voice at Playboy Mansion (voice)

Rick Pasqualone

Character: Utility Voice

Django Marsh

Character: Young E.B. (voice)

Robbie Tucker

Character: Kid#1 (uncredited)

Crystal the Monkey

Character: Monkey (uncredited)

Michaël Grégorio

Character: (voice) (uncredited)