Christine Cavanaugh

Character: Charles 'Chuckie' Finster Jr. (voice)

Cheryl Chase

Character: Angelica C. Pickles (voice)

Kath Soucie

Character: Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice)

Tara Strong

Character: Dylan Prescott 'Dil' Pickles (voice)

Cree Summer

Character: Susan 'Susie' Carmichael (voice)

Tress MacNeille

Character: Charlotte C. Pickles (voice)

Melanie Chartoff

Character: Didi Pickles (voice)

Jack Riley

Character: Stu Pickles (voice)

Joe Alaskey

Character: Louis 'Grandpa' Pickles (voice)

Michael Bell

Character: Drew Pickles/Charles 'Chaz' Finster, Sr. (voice)

Charlie Adler

Character: Professor Spooky (voice)

E. G. Daily

Character: Tommy Pickles (voice)