Tobey Maguire

Character: Spider-Man / Peter Parker

Willem Dafoe

Character: Green Goblin / Norman Osborn

Kirsten Dunst

Character: Mary Jane Watson

James Franco

Character: Harry Osborn

Cliff Robertson

Character: Ben Parker

Rosemary Harris

Character: May Parker

J.K. Simmons

Character: J. Jonah Jameson

Joe Manganiello

Character: Flash Thompson

Gerry Becker

Character: Maximilian Fargas

Bill Nunn

Character: Joseph 'Robbie' Robertson

Jack Betts

Character: Henry Balkan

Stanley Anderson

Character: General Slocum

Ron Perkins

Character: Dr. Mendel Stromm

Michael Papajohn

Character: Carjacker

K.K. Dodds

Character: Simkins

Ted Raimi

Character: Hoffman

Bruce Campbell

Character: Ring Announcer

Elizabeth Banks

Character: Miss Brant

John Paxton

Character: Houseman

Tim DeZarn

Character: Philip Watson

Taylor Gilbert

Character: Madeline Watson

Randy Poffo

Character: Bone Saw McGraw

Larry Joshua

Character: Wrestling Promoter

Timothy Patrick Quill

Character: Wrestling Arena Guard

Lisa Danielle

Character: Bone-ette

Natalie T. Yeo

Character: Bone-ette

Erica D. Porter

Character: Bone-ette

Kristen Davidson

Character: Bone-ette

Jason Padgett

Character: Flash's Crony

Shan Omar Huey

Character: Teacher

Sally Levi

Character: Girl on Bus

Evan Arnold

Character: Doctor

Jill Sayre

Character: Nurse

Jim Ward

Character: Project Coordinator

David Holcomb

Character: Test Pilot

Octavia Spencer

Character: Check-In Girl

Brad Grunberg

Character: Heckler

Shane Habberstad

Character: Little Billy

Deborah Wakeham

Character: Billy's Mom

Rachael Bruce

Character: Times Square Child

Mackenzie Bryce

Character: Times Square Child

Julia Barrie

Character: Times Square Child

Macy Gray

Character: Macy Gray

Myk Watford

Character: Cop at Fire

Bill Calvert

Character: Fireman

Sylva Kelegian

Character: Mother at Fire

Kristen Marie Holly

Character: Young Lady at Fire

Ajay Mehta

Character: Cabbie

Peter Appel

Character: Cabbie

Scott Spiegel

Character: Marine Cop

Matt Smith

Character: Cop at Carjacking

Sara Ramirez

Character: Cop at Carjacking

Lucy Lawless

Character: Punk Rock Girl

Jayce Bartok

Character: Subway Guitarist

Maribel González

Character: Lady Dogwalker

Amy Bouril

Character: Office Lady

Joseph D'Onofrio

Character: Opinionated Cop

Jim Norton

Character: Surly Truck Driver

Corey Mendell Parker

Character: Chaperone in Tram

Ashley Edner

Character: Girl in Tram

William Joseph Firth

Character: Boy in Tram

Alex Black

Character: Boy in Tram

Laura Gray

Character: Tram Group Mother

Joe Virzi

Character: New Yorker on Bridge

Michael Edward Thomas

Character: New Yorker on Bridge

Jeanie Fox

Character: New Yorker on Bridge

Robert Kerman

Character: Tugboat Captain

Stan Lee

Character: Man in Fair (uncredited)

Una Damon

Character: Lab Tour Guide (uncredited)

Rick Avery

Character: Cop (uncredited)

Peter Aylward

Character: Colonel (uncredited)

Jillian Clare

Character: Crying Girl in Tram (uncredited)

Chris Coppola

Character: Kyle (uncredited)

Jesse Heiman

Character: Spectator at School Fight (uncredited)

Leroy Patterson

Character: World Unity Festival Attendant (uncredited)

Benny Urquidez

Character: Mugger (uncredited)

Scott L. Schwartz

Character: Screaming Wrestler (uncredited)

Jophery C. Brown

Character: Chef (uncredited)

Brian J. Williams

Character: Young Thug #2 (uncredited)

Mark De Alessandro

Character: Cop (uncredited)

Tia Dionne Hodge

Character: Uptown Woman (uncredited)

Loren Janes

Character: Board of Directors Member (uncredited)

Andray Johnson

Character: Balkan's Aide (uncredited)

Martin Pfefferkorn

Character: Thug on 8x10 (uncredited)

Tammi Sutton

Character: Street Vendor (uncredited)

Lindsay Thompson

Character: Mary Jane's Friend (uncredited)

Sean Valla

Character: Boat Light Man (uncredited)

Pete Macnamara

Character: Pentagon Officer (uncredited)

Al Goto

Character: Cop (uncredited)

Joni Avery

Character: Cop (uncredited)

Sam Raimi

Character: Popcorn Thrower (uncredited)

Craig 'Radio Man' Castaldo

Character: Man with Bike (uncredited)

Lou Torres

Character: Enrique