Tobey Maguire

Character: Spider-Man / Peter Parker

Kirsten Dunst

Character: Mary Jane Watson

James Franco

Character: Harry Osborn

Alfred Molina

Character: Doc Ock / Otto Octavius

Rosemary Harris

Character: May Parker

J.K. Simmons

Character: J. Jonah Jameson

Donna Murphy

Character: Rosalie Octavius

Daniel Gillies

Character: John Jameson

Dylan Baker

Character: Dr. Curt Connors

Bill Nunn

Character: Joseph 'Robbie' Robertson

Vanessa Ferlito

Character: Louise

Aasif Mandvi

Character: Mr. Aziz

Willem Dafoe

Character: Green Goblin / Norman Osborn

Cliff Robertson

Character: Ben Parker

Ted Raimi

Character: Hoffman

Elizabeth Banks

Character: Miss Brant

Bruce Campbell

Character: Snooty Usher

Gregg Edelman

Character: Dr. Davis

Ilya Baskin

Character: Mr. Ditkovitch

Mageina Tovah

Character: Ursula

Daniel Dae Kim

Character: Raymond

Hal Sparks

Character: Elevator Passenger

Joel McHale

Character: Mr. Jacks

Stan Lee

Character: Man Dodging Debris

Kelly Connell

Character: Dr. Isaacs

Brent Briscoe

Character: Garbage Man

Emily Deschanel

Character: Receptionist

Jason Fiore-Ortiz

Character: Henry Jackson

Scott Spiegel

Character: Man on Balcony

Andy Bale

Character: OsCorp Executive

Christine Estabrook

Character: Mrs. Jameson

Molly Cheek

Character: Society Woman

John Paxton

Character: Houseman

Joy Bryant

Character: Woman at Web

Joanne Baron

Character: Skeptical Scientist

Peter McRobbie

Character: OsCorp Representative

Timothy Jerome

Character: Injured Scientist

Taylor Gilbert

Character: Mrs. Watson

Peter Vouras

Character: Stage Manager

Donnell Rawlings

Character: Pizza "Heist" Witness

Zachry Rogers

Character: Boy saved by Spider-Man

Ella Rogers

Character: Girl saved by Spider-Man

Louis Lombardi

Character: Poker Player

Marc John Jefferies

Character: Amazed Kid

Roshon Fegan

Character: Amazed Kid

Brendan Patrick Connor

Character: Theater Traffic Cop

Reed Diamond

Character: 'Algernon'

Dan Callahan

Character: 'Jack'

Elyse Dinh

Character: Violinist

John Landis

Character: Doctor

Tim Storms

Character: Chainsaw Doctor

Susie Park

Character: Clawing Nurse

Patricia M. Peters

Character: Screaming Nurse

Michael Edward Thomas

Character: Man at Fire

Anne Betancourt

Character: Woman at Fire

Venus Lam

Character: Child in Burning Building

Bill E. Rogers

Character: Fireman

Joe Virzi

Character: Fireman

Tom Carey

Character: Train Conductor

Jopaul Van Epp

Character: Boy with Mask

Weston Epp

Character: Boy with Mask

Peter Allas

Character: Train Passenger

Brianna Brown

Character: Train Passenger

Bill Calvert

Character: Train Passenger

Tony Campisi

Character: Train Passenger

Joey Diaz

Character: Train Passenger

Chloe Dykstra

Character: Train Passenger

Simone Gordon

Character: Train Passenger

Dan Hicks

Character: Train Passenger

Julia Max

Character: Train Passenger

Savannah Pope

Character: Train Passenger

Timothy Patrick Quill

Character: Train Passenger

Jill Sayre

Character: Train Passenger

Rickey G. Williams

Character: Train Passenger

Michael Arthur

Character: NYPD Officer (uncredited)

Frank Bonsangue

Character: Pizza Man (uncredited)

Cindy Cheung

Character: Chinese Daughter (uncredited)

Phil LaMarr

Character: Train Passenger (uncredited)

Andre M. Johnson

Character: Fireman 2 (uncredited)

Peter Cincotti

Character: Piano Player in Planetarium (uncredited)

Troy Metcalf

Character: Blue Collar Guy (uncredited)

Scott Ross

Character: Pedestrian (uncredited)

Bonnie Somerville

Character: Screaming Woman (uncredited)

Wesley Volcy

Character: Columbia University Student (uncredited)

Lou Volpe

Character: Man at Web (uncredited)

Garrett Warren

Character: Bearded Doctor (uncredited)

Joseph M. Caracciolo

Character: Priest at Mary Jane's Wedding (uncredited)

David Boston

Character: Pedestrian (uncredited)

Sho Brown

Character: Passenger (uncredited)

Sal Ardisi

Character: Parent (uncredited)

Edward Johnson

Character: Planetarium (uncredited)

Grant Curtis

Character: Hot Dog Vendor (uncredited)

Vince Cupone

Character: Victim (uncredited)

William E. Corcoran

Character: Stock Broker (uncredited)

Mohammed Hassan

Character: Middle Eastern Taxi Driver (uncredited)

Rachel Lehrer

Character: Hot Girl (uncredited)

Gene LeBell

Character: Train Passenger (uncredited)

Lorelei Llee

Character: Bank Employee (uncredited)

Joseph Nelson

Character: Extra (uncredited)

Claudia Katz Minnick

Character: Robbie's Assistant (uncredited)

Ronn Ozuk

Character: Cop (uncredited)

Denney Pierce

Character: Train Passenger (uncredited)

Carla Rhodes

Character: Phone Booth Girl (uncredited)

Randy Reinholz

Character: Train Passenger (uncredited)

Rachelle Roderick

Character: Jane, Engineer (uncredited)

Angel Katherine Taormina

Character: Female Onlooker on Street (uncredited)

Douglas Swander

Character: Train Passenger (uncredited)

Jimmy Star

Character: Reporter (uncredited)

Jack Wetherall

Character: Train Passenger (uncredited)

Ken Wharton

Character: Uptight Businessman (uncredited)

Henry Truong

Character: Doc Ock Lab Assistant #2 (uncredited)

Al Collado

Character: Cab Driver (uncredited)

Lee Cogburn

Character: Train Passenger (uncredited)

Sam Raimi

Character: University Student with Bag (uncredited)

John Cameron

Character: Man Buying 'Spider-Man No More' Newspaper (uncredited)