Kiefer O'Reilly

Character: Howard Lovecraft (Voice)

Jeffrey Combs

Character: H.P. Lovecraft (voice)

Tyler Nicol

Character: Winfield Lovecraft (voice)

Michelle Myers

Character: Sarah Lovecraft (voice)

Sean Patrick O'Reilly

Character: Spot / Cthulhu (voice)

Alison Wandzura

Character: Mary Lovecraft (voice)

Mark Hamill

Character: Dr. Henry Armitage (voice)

Vijary Vaibhav Saini

Character: Professor Jaswant Atwood (voice)

Ashleigh Ball

Character: Ellen Ellery (voice)

Scott McNeil

Character: Hamish Rice / Govlins (voice)

Nick Wolfhard

Character: William Dyer (voice)

Christopher Plummer

Character: Dr. Jeffrey West (voice)

Finn Wolfhard

Character: Herbert West (voice)

Doug Bradley

Character: Nyarlathotep (voice)

Summer O'Reilly

Character: Gotha (voice)

Harmony O'Reilly

Character: Innes (voice)

Phoenix O'Reilly

Character: Twi'i (voice)