Charlize Theron

Character: Mavis Gary

Patton Oswalt

Character: Matt Freehauf

Patrick Wilson

Character: Buddy Slade

Elizabeth Reaser

Character: Beth Slade

Collette Wolfe

Character: Sandra Freehauf

Jill Eikenberry

Character: Hedda Gary

Richard Bekins

Character: David Gary

Mary Beth Hurt

Character: Jan

Kate Nowlin

Character: Mary Ellen Trantowski

Jenny Dare Paulin

Character: Nipple Confusion Bassist

Rebecca Hart

Character: Nipple Confusion Guitarist

Louisa Krause

Character: Front Desk Girl

Elizabeth Ward Land

Character: Sales Lady

Brian McElhaney

Character: Book Associate

Hettienne Park

Character: Vicki

John Forest

Character: Wheelchair Mike

Rightor Doyle

Character: Babysitter

Brady Smith

Character: Date Man

Tim Young

Character: Champions Server

Erin Darke

Character: Teen Employee

Jee Young Han

Character: Teen Employee

Ella Rae Peck

Character: Girl

Aleisha Allen

Character: Girl

Matt Wilson

Character: Teenage Clerk

Orlagh Cassidy

Character: Party Guest

Charles Techman

Character: Parking Attendant

Emily Meade

Character: Denny's Waitress

Neil Hellegers

Character: Young Dad

Michael Nathanson

Character: Champions Greeter

Landyn Banx

Character: Business Person (uncredited)

Kirsten Gregerson

Character: Business Person (uncredited)

J.K. Simmons

Character: Mavis' Publisher (voice) (uncredited)

Joel Thingvall

Character: Businessman in Skyway (uncredited)

Julie E. Davis

Character: Shopper (uncredited)

Fredrika Dukes

Character: Business Person (uncredited)

John Edel

Character: Businessman in Skyway (uncredited)

Rosemary Howard

Character: Guest at Baby Naming Party (uncredited)

Eric Pierson

Character: Restaurant Patron (uncredited)