Jim Carrey

Character: Mr. Popper

Carla Gugino

Character: Amanda

Angela Lansbury

Character: Mrs. Van Gundy

Ophelia Lovibond

Character: Pippi

Madeline Carroll

Character: Janie

Clark Gregg

Character: Nat Jones

Jeffrey Tambor

Character: Mr. Gremmins

David Krumholtz

Character: Kent

Philip Baker Hall

Character: Franklin

Maxwell Perry Cotton

Character: Billy

James Tupper

Character: Rick

Dominic Chianese

Character: Reader

William Charles Mitchell

Character: Yates

Henry Kelemen

Character: Young Tommy Popper

Kelli Barrett

Character: Tommy's Mom

Dylan Clark Marshall

Character: Young Tommy Popper #2

Brian T. Delaney

Character: Young Tom Popper, Sr. (voice)

Elaine Kussack

Character: Gremmins's Secretary

Harlin C. Kearsley

Character: Town Car Driver

Desmin Borges

Character: Daryl

Lee Moore

Character: Reginald

Dominic Colón

Character: Tito

Jeff Lima

Character: Freddy

Frank Ciornei

Character: Klaus

J.R. Horne

Character: Arnold

Matthew Wolf

Character: Antarctic Friend (voice)

Andrew Stewart-Jones

Character: Animal Control Guy

James Chen

Character: Fish & Game Officer

Rafael Osorio

Character: Marine & Waterfowl Officer

Curtis Shumaker

Character: Sanitation Officer

Joseph D'Onofrio

Character: Random Man on Street

Olga Merediz

Character: Nanny

Betsy Aidem

Character: Tavern Hostess

Angel Caban

Character: Fishmonger

Chris Beetem

Character: Young Developer

Charles L. Campbell

Character: Old Tom Popper, Sr. (voice)

Daniel Stewart Sherman

Character: Zoo Security Guard

Mike Massimino

Character: Cop #1

Charlie Semine

Character: Cop #2 (Quint)

Cynthia Kirchner

Character: Pulse Lounge Beautiful Girl (uncredited)