Hilary Swank

Character: Claire Morgan

Robert De Niro

Character: Stan Harris

Michelle Pfeiffer

Character: Ingrid Withers

Josh Duhamel

Character: Sam

Sarah Jessica Parker

Character: Kim Doyle

Zac Efron

Character: Paul

Lea Michele

Character: Elise

Ashton Kutcher

Character: Randy

Halle Berry

Character: Nurse Aimee

Jon Bon Jovi

Character: Daniel Jensen

Katherine Heigl

Character: Laura Carrington

Seth Meyers

Character: Griffin Byrne

Jessica Biel

Character: Tess Byrne

Til Schweiger

Character: James Schwab

Carla Gugino

Character: Spiritual Dr. Morriset

Cary Elwes

Character: Stan's Doctor

Sofía Vergara

Character: Ava

Héctor Elizondo

Character: Kominsky

Abigail Breslin

Character: Hailey Doyle

Ludacris

Character: Brendan

Sarah Paulson

Character: Grace Schwab

Alyssa Milano

Character: Nurse Mindy

Jake T. Austin

Character: Seth

Katherine McNamara

Character: Lily Bowman

Nat Wolff

Character: Walter

Yeardley Smith

Character: Maude

Ryan Seacrest

Character: Self

Michael Bloomberg

Character: Self

Fiona Choi

Character: Balinese Woman - Resolution Tour

Jim Belushi

Character: Building Super

Mara Davi

Character: Mika

Cassidy Reiff

Character: Piper

Russell Peters

Character: Chef Sunil

Serena Poon

Character: Chef Ming

Common

Character: Soldier

Jackie Seiden

Character: Bride Trish

Joey McIntyre

Character: Groom Rory

Beth Kennedy

Character: Piper's Mom

Larry Miller

Character: Harley (segment "Ahern Party")

Christine Lakin

Character: Waitress Alyssa

Shea Curry

Character: Wendy

Sandra Taylor

Character: Patty

Matthew Broderick

Character: Mr. Buellerton (uncredited)

John Lithgow

Character: Jonathan Cox (uncredited)

Juliette Angelo

Character: Sadie

Mary Marguerite Keane

Character: Pet Adoption Clerk

Barbara Marshall

Character: Head Nurse Helen

Lillian Lifflander

Character: Mrs Lifflander

Penny Marshall

Character: Penny Marshall

Cherry Jones

Character: Mrs Rose Ahern

Charlotte Marshall-Fricker

Character: Caring Teenage Girl (segment "Resolution Tour")

Michael Mandell

Character: Murray (segment "Resolution Tour")

Patrick Reale

Character: Times Square Cop (segment "Resolution Tour")