Adam Devine

Character: Ed (voice)

Rachel Bloom

Character: Op (voice)

Zazie Beetz

Character: Dottie (voice)

Ken Jeong

Character: Clarance (voice)

Jim Jefferies

Character: Burnie (voice)

Catherine O'Hara

Character: Alma (voice)

Reggie Watts

Character: Hoss / Ernest Shackleton (voice)

Henry Winkler

Character: Jepson (voice)

Alex Borstein

Character: Mali (voice)

Benedict Wong

Character: Dr. Chung (voice)

Julia Chan

Character: Mrs. Sun / Little Girl (voice)

Tom Hollander

Character: Charles Darwin (voice)

Richard Kind

Character: Wally (voice)

Steve Aoki

Character: Vinny (voice)

Nick Frost

Character: Captain (voice)

Jon Lovitz

Character: Conch (voice)

Sydney Liu

Character: Bo (voice)

Maria Bamford

Character: Bo's Mom (voice)

Raymond S. Persi

Character: That Guy / Booby (voice)

Terry Gross

Character: Bomb (voice)

David Silverman

Character: Cyclops / Donut Store Clerk (voice)

Kelly Hu

Character: News Reporter (voice)

Tom Kenny

Character: Mozart / Sled Dogs (voice)

Jason Hightower

Character: Narrator / Sled Dogs (voice)

Kevin Michael Richardson

Character: Sled Dogs (voice)

Brenden P. Hill

Character: Baseball Announcer (voice)