Steve Martin

Character: Stu Preissler

Jack Black

Character: Brad Harris

Owen Wilson

Character: Kenny Bostick

Brian Dennehy

Character: Raymond Harris

Anjelica Huston

Character: Annie Auklet

Rashida Jones

Character: Ellie

Rosamund Pike

Character: Jessica

Dianne Wiest

Character: Brenda Harris

JoBeth Williams

Character: Edith

Anthony Anderson

Character: Bill Clemont

Corbin Bernsen

Character: Gil Gordon

Barry Shabaka Henley

Character: Dr. Neil Kramer

Joel McHale

Character: Barry Loomis

Tim Blake Nelson

Character: Fuchs

Jim Parsons

Character: Crane

Kevin Pollak

Character: Jim Gittelson

Nate Torrence

Character: Ted Simkin

Steven Weber

Character: Rick

Zahf Paroo

Character: Prasad

John Cleese

Character: Historical Montage Narrator (voice)

Paul Campbell

Character: Tony

Cindy Busby

Character: Susie

Greg Kean

Character: Computer Birder

Eva Bourne

Character: Birder's Daughter

Bill Dow

Character: Dr. Paul Elkin

June Squibb

Character: Old Lady

Craig Bockhorn

Character: Lawyer

Joey Aresco

Character: Frank Falucci

Ryan Caltagirone

Character: Frank Jr.

Al Roker

Character: New York Weatherman

Christopher Mann

Character: Security Guard

Jan Bos

Character: Local Newsman (High Island)

Kate Gajdosik

Character: Local Newswoman (High Island)

William Samples

Character: British Tourist

Scott Patey

Character: Birder (High Island)

Marci T. House

Character: Troop Leader

Michael Bean

Character: Waiter

Christopher Redman

Character: Scott

Devon Weigel

Character: Karen

Andrew Wilson

Character: Mike Shin

Gabrielle Rose

Character: Mary Swit

Calum Worthy

Character: Colin Debs

Doreen Ramus

Character: CB Announcer

Terence Kelly

Character: Pete Shackelford

Steve Darling

Character: Anchorage Weatherman

Jon Frankel

Character: Anchorage Anchorman

David James Lewis

Character: Lanky Birder

Jesse Moss

Character: Darren

Kath Dugray

Character: Motel Manager

Morgan Brayton

Character: Ferry Ticket Seller

Sheelah Megill

Character: Nurse

Veena Sood

Character: Nurse Katie

Dee Jay Jackson

Character: Parking Attendant

Calvin Lee

Character: Chinese Waiter

Tshering Garie

Character: Chinese Waitress

Michael Karl Richards

Character: Vicki's Fiancée (uncredited)

Stacey Scowley

Character: Vicki (uncredited)