Patricia Clarkson

Character: Mia

Rosario Dawson

Character: Lili

Lyndsy Fonseca

Character: Cheyanne

Ginnifer Goodwin

Character: Charlotte

Jeanne Tripplehorn

Character: Pearl

Emily Skinner

Character: Sally

Carla Gallo

Character: Laura

Aisha Hinds

Character: Bernice

Josh Holloway

Character: Bill

Jennifer Morrison

Character: Sheila

Austin Nichols

Character: Edward

Annie Potts

Character: Helen

Xander Berkeley

Character: Peter

Kathy Najimy

Character: Rocky

Romy Rosemont

Character: Lynne

Tony Shalhoub

Character: Mitch

Jenifer Lewis

Character: Maggie

Tracee Ellis Ross

Character: Alyssa

Jeffrey Tambor

Character: Danny

David Eigenberg

Character: Lenny

Taylor Kinney

Character: Tommy

Bob Newhart

Character: Dr. Roth

Ravi Patel

Character: Dr. Desai

Alan Ruck

Character: Sam Jarente

Scott Wilson

Character: Bill (Older)

Kirk Baily

Character: Scott

Israel Sáez de Miguel

Character: Dimitri

Ava Acres

Character: Pearl at age 7

Josh Dallas

Character: Henry

Harmon Jones

Character: Ben