Seth Rogen

Character: Andy Brewster

Barbra Streisand

Character: Joyce Brewster

Yvonne Strahovski

Character: Jessica

Colin Hanks

Character: Rob

Brett Cullen

Character: Ben

Adam Scott

Character: Andrew Margolis Jr.

Ari Graynor

Character: Joyce Margolis

Kathy Najimy

Character: Gayle

Danny Pudi

Character: Sanjay

Casey Wilson

Character: Amanda

Dale Dickey

Character: Tammy

Brandon Keener

Character: Ryan Mcfee

Robert Curtis Brown

Character: Bob Ferguson

Nora Dunn

Character: Amy

Miriam Margolyes

Character: Anita

Rose Abdoo

Character: Diana

Analeis Anderson

Character: Moonlight

Gabrielle Gumbs

Character: Stripper

Rick Gonzalez

Character: Mark

Worth Howe

Character: Bob

Vicki Goldsmith

Character: Young Joyce

Constance Esposito

Character: HSN Executive

Creed Bratton

Character: Suitor

Jeff Kober

Character: Jimmy

Tom Virtue

Character: Mature Singles Man

John Funk

Character: K-Mart Executive

Julene Renee

Character: K-Mart Receptionist (as Julene Renee-Preciado)

Matthew Levinson

Character: Toddler Andy

Vivian Vanderwerd

Character: Mature Singles Woman

Zabryna Guevara

Character: K-Mart Executive

Michael Cassidy

Character: Fake Andy (uncredited)