E. G. Daily

Character: Tommy Pickles (voice)

Christine Cavanaugh

Character: Chuckie Finster (voice)

Kath Soucie

Character: Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cree Summer

Character: Susie Carmichael / Edwin Carmichael (voice)

Dionne Quan

Character: Kimi Finster (voice)

Ron Glass

Character: Randy Carmichael (voice)

Irma P. Hall

Character: Aunt T. (voice)

Crystal Scales

Character: Buster Carmichael (voice)

Hattie Winston

Character: Lucy Carmichael / Lucy's Mom (voice)

Kimberly Brooks

Character: Young Lucy (voice)

Bill Cobbs

Character: Uncle Charles (voice)

Erv Immeman

Character: Radio Announcer (voice)

Kevin Michael Richardson

Character: Martin Luther King Jr. (voice)

Cynthia Kaye Hunt

Character: Choir Soloist (voice)

Joe Alaskey

Character: Grandpa Lou Pickles (voice)

Sam Saletta

Character: Additional Voices (voice)

Bettina Bush

Character: Alisa Carmichael (voice)