John Barrymore

Character: Riviere

Helen Hayes

Character: Madame Fabian

Clark Gable

Character: Jules

Lionel Barrymore

Character: Robineau

Robert Montgomery

Character: Auguste Pellerin

Myrna Loy

Character: Wife of Brazilian Pilot

William Gargan

Character: Brazilian Pilot

C. Henry Gordon

Character: Daudet

Leslie Fenton

Character: Jules' Radio Operator / Co-Pilot

Harry Beresford

Character: Pierre Roblet

Frank Conroy

Character: Radio Operator

Dorothy Burgess

Character: Pellerin's Girlfriend

Irving Pichel

Character: Dr. Decosta

Helen Jerome Eddy

Character: Worried Mother

Buster Phelps

Character: Sick Child

Ralf Harolde

Character: Pilot

Marcia Ralston

Character: Nightclub Vamp

Maurice Black

Character: Nightclub Manager (uncredited)

Ed Brady

Character: Radio Operator on Telephone (uncredited)

Sidney D'Albrook

Character: Airport Office Employee (uncredited)

Claire Du Brey

Character: Santiago Nurse (uncredited)

Sherry Hall

Character: Airport Office Employee (uncredited)

Otto Hoffman

Character: Airport Office Clerk (uncredited)

George Irving

Character: Santiago Doctor (uncredited)

Wallace MacDonald

Character: Mechanic (uncredited)

Michael Mark

Character: Airport Office Employee (uncredited)

Francis McDonald

Character: Radioman (uncredited)

Louis Natheaux

Character: Radioman (uncredited)

Inez Palange

Character: Simone's Maid (uncredited)

Edward Peil Sr.

Character: Airport Office Employee (uncredited)

Evelyn Selbie

Character: Mother in Window (uncredited)