John Goodman

Character: Fred Flintstone

Elizabeth Perkins

Character: Wilma Flintstone

Rick Moranis

Character: Barney Rubble

Rosie O'Donnell

Character: Betty Rubble

Kyle MacLachlan

Character: Cliff Vandercave

Halle Berry

Character: Sharron Stone

Elizabeth Taylor

Character: Pearl Slaghoople

Dann Florek

Character: Mr. Slate

Richard Moll

Character: Hoagie

Irwin Keyes

Character: Joe Rockhead

Jonathan Winters

Character: Gobo The Grizzled Man

Harvey Korman

Character: Ali / Dicabird / Blossom's Adopted Doll Son Ali

Lainey Silver

Character: Pebbles

Melanie Silver

Character: Pebbles

Hlynur Sigurðsson

Character: Bamm-Bamm

Marinó Sigurðsson

Character: Bamm-Bamm

Sheryl Lee Ralph

Character: Mrs. Pyrite

Jean Vander Pyl

Character: Mrs. Feldspar

Janice Kent

Character: Stewardess

Jack O'Halloran

Character: Yeti

Becky Thyre

Character: Roxanne

Rod McCary

Character: Store Manager

Kate Pierson

Character: BC-52's

Fred Schneider

Character: BC-52's

Keith Strickland

Character: BC-52's

Jim Doughan

Character: Maitre d'

Laraine Newman

Character: Susan Rock

Jay Leno

Character: Bedrock's Most Wanted Host

Alan Blumenfeld

Character: Fred Look-A-Like

Messiri Freeman

Character: Miss Stone Look-A-Like

Alex Zimmerman

Character: Accuser

Sam Raimi

Character: Cliff Look-A-Like

Tommy Terrell

Character: Accuser

Andy Steinfeld

Character: Aerobics Instructor

Bradford Bryson

Character: Foreman

Tabbie Brown

Character: Accuser

Dean Cundey

Character: Technician

Lita Stevens

Character: Woman at Chevrox

Joseph Barbera

Character: Man in Mersandes

William Hanna

Character: Executive in Boardroom

Mel Blanc

Character: Dino (voice) (archive sound)

Sam the Orangutan

Character: Mr. Henderson (uncredited)