Nathan Fillion

Character: Bill Pardy

Michael Rooker

Character: Grant Grant

Elizabeth Banks

Character: Starla Grant

Gregg Henry

Character: Jack MacReady

Tania Saulnier

Character: Kylie Strutemyer

Don Thompson

Character: Wally

Brenda James

Character: Brenda Gutierrez

Jennifer Copping

Character: Margaret

Jenna Fischer

Character: Shelby

Haig Sutherland

Character: Trevor

William MacDonald

Character: Mr. Strutemyer

Iris Quinn

Character: Mrs. Strutemyer

Matreya Fedor

Character: Emily Strutemyer

Amber Lee Bartlett

Character: Jenna Strutemyer

Xantha Radley

Character: Uptight Mom

Dustin Milligan

Character: Drawing Boy

Lloyd Kaufman

Character: Sad Drunk

Zak Ludwig

Character: Gina Kid

Tom Heaton

Character: Tourneur

Mary Black

Character: Woman in Basement

Ben Cotton

Character: Charlie

Lorena Gale

Character: Janene

Dee Jay Jackson

Character: Dwight

Nicholas Podbrey

Character: Diseased Grant part 1

Malcolm Scott

Character: Dude Joining Grant

Darren Shahlavi

Character: Brenda's Husband

Kathryn Kirkpatrick

Character: Karaoke Woman

Corb Lund

Character: Lead Singer

Michael Cromien

Character: Fitzgibbon

Robert Musnicki

Character: Diseased Leader

Stephen Park

Character: Gleeked on Guy

Nicholas Podbrey

Character: Diseased Grant #1

Jeny Cassady

Character: Diseased Grant #2

Alette Falle

Character: Diseased Grant #3

Matt McInnis

Character: Head-Shot Norman

James Gunn

Character: Hank (uncredited)

Magda Apanowicz

Character: Friend (uncredited)

Rick Morwick

Character: Truck Driver (uncredited)

Rob Zombie

Character: Dr. Karl (voice)

Mark Torgl

Character: Melvin Junko (Archive footage)