Johnny Depp

Character: William Blake

Gary Farmer

Character: Nobody

Crispin Glover

Character: Train Fireman

Lance Henriksen

Character: Cole Wilson

Michael Wincott

Character: Conway Twill

Eugene Byrd

Character: Johnny 'The Kid' Pickett

John Hurt

Character: John Scholfield

Robert Mitchum

Character: John Dickinson

Iggy Pop

Character: Salvatore 'Sally' Jenko

Gabriel Byrne

Character: Charlie Dickinson

Jared Harris

Character: Benmont Tench

Mili Avital

Character: Thel Russell

Jimmie Ray Weeks

Character: Marvin, Older Marshal

Mark Bringelson

Character: Lee, Younger Marshal

John North

Character: Mr. Olafsen

Alfred Molina

Character: Trading Post Missionary

Billy Bob Thornton

Character: Big George Drakoulious

Michelle Thrush

Character: Nobody's Girlfriend

Gibby Haynes

Character: Man with Gun in Alley

Richard Boes

Character: Man with Wrench