Daniel Radcliffe

Character: 'Weird Al' Yankovic

Evan Rachel Wood

Character: Madonna

Rainn Wilson

Character: Dr. Demento

Toby Huss

Character: Nick Yankovic

Jack Lancaster

Character: Jim

Spencer Treat Clark

Character: Steve

Tommy O'Brien

Character: Bermuda

Arturo Castro

Character: Pablo Escobar

Julianne Nicholson

Character: Mary Yankovic

Diedrich Bader

Character: Grizzled Narrator (voice)

Lin-Manuel Miranda

Character: Doctor

Richard Aaron Anderson

Character: Young Al

Thomas Lennon

Character: Salesman

David Bloom

Character: Teenage Al

Keanush Tafreshi

Character: Kip

Andrew Steven Hernandez

Character: Robbie

Paloma Esparza Rabinov

Character: Hipster Teen

Scott Aukerman

Character: Police Officer

Johnny Pemberton

Character: Johnny Barf

Jonah Ray Rodrigues

Character: Jonah Barf

Jeremy Bolm

Character: Jeremy Barf

Eric Appel

Character: Captain Buffoon (voice)

'Weird Al' Yankovic

Character: Tony Scotti

Will Forte

Character: Ben Scotti

Patton Oswalt

Character: Heckler

Michael McKean

Character: Sleazy MC

Dot-Marie Jones

Character: Mama Bear

Dean Sharpe

Character: Bartender

Jorma Taccone

Character: Pee-Wee Herman

Demetri Martin

Character: Tiny Tim

Paul F. Tompkins

Character: Gallagher

Akiva Schaffer

Character: Alice Cooper

Conan O'Brien

Character: Andy Warhol

Emo Philips

Character: Salvador Dali

Nina West

Character: Divine

Jack Black

Character: Wolfman Jack

David Dastmalchian

Character: John Deacon

Anthony N.

Character: Security Guard

Quinta Brunson

Character: Oprah Winfrey

Julie Chang

Character: Connie Chung

Josh Groban

Character: Waiter

Seth Green

Character: Radio DJ (voice)

Constantine Rousouli

Character: Cone-Bra Dancer #1

James Brown III

Character: Cone-Bra Dancer #2

Rocky Abou-Sakher

Character: Terrorist Diner Patron

Chris Ryan

Character: Kidnapper

Mike Escamilla

Character: Guard #1

Chad Guerrero

Character: Guard #2

Cesar Ramirez

Character: Mariachi Band Member #1

Omar Estrada

Character: Mariachi Band Member #2

Cesar Chavira

Character: Mariachi Band Member #3

Jimmy Walker Jr.

Character: Floor Manager

Trenyce

Character: Diana Ross

James Preston Rogers

Character: Hulk Hogan

William Guirola

Character: Sicario

Paul Riley Fox

Character: Elton John (uncredited)

Gordon Tarpley

Character: David Bowie (uncredited)

Lisa Margaroli

Character: Elvira, Mistress of the Dark (uncredited)

Erin O'Shea

Character: Kate Pierson (uncredited)

James Hunter

Character: Paparazzi (uncredited)