John Travolta

Character: James

Kirstie Alley

Character: Mollie

Olympia Dukakis

Character: Rosie

Elias Koteas

Character: Stuart

Twink Caplan

Character: Rona

Bruce Willis

Character: Mikey (voice)

Roseanne Barr

Character: Julie (voice)

Damon Wayans

Character: Eddie (voice)

Gilbert Gottfried

Character: Joey

Mel Brooks

Character: Mr. Toilet Man (voice)

Lorne Sussman

Character: Mikey

Megan Milner

Character: Julie (1 year)

Georgia Keithley

Character: Julie (4 months)

Nikki Graham

Character: Julie (newborn)

Danny Pringle

Character: Eddie

Neal Israel

Character: Mr. Ross

Lesley Ewen

Character: Debbie

Noelle Parker

Character: Woman Client

Douglas Warhit

Character: Man Client

Terry David Mulligan

Character: IRS Inspector

Paul Shaffer

Character: Taxi Businessman

Don S. Davis

Character: Dr. Fleischer

Morris Panych

Character: Arrogant Businessman

Alex Bruhanski

Character: Needle Doctor

Dorothy Fehr

Character: Blonde

Heather Lea Gerdes

Character: Hot Babe on Fire Escape

Robin Trapp

Character: Cool Chick

Rick Avery

Character: Burglar

Stephen Dimopoulos

Character: Fire Chief

Jimmy Galeota

Character: Punk Baby

Frank Totino

Character: Candy Man

Coleman Lumley

Character: Blonde Baby

Constance Barnes McCansh

Character: Sexy Dancer

Ruby J. Munro

Character: Businessman's Babe

Mollie Heckerling

Character: Mikey's Dream Friend

Alicia Mizel

Character: Slob Child

Denis Corbett

Character: Cop (uncredited)

Yolanda Corbett

Character: Shopper (uncredited)